Abstract
To test the hypothesis that bacterial contamination of menstrual blood could be a local biologic event in the development of endometriosis, menstrual blood was cultured and bacterial endotoxin was measured in menstrual blood and peritoneal fluid. Our results suggest that compared with control women, higher colony formation of Escherichia coli in menstrual blood and endotoxin levels in menstrual fluid and peritoneal fluid in women with endometriosis may promote Toll-like receptor 4-mediated growth of endometriosis.
Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Ascitic Fluid / chemistry
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Ascitic Fluid / microbiology
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Ascitic Fluid / pathology
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Blood / microbiology
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Case-Control Studies
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Cells, Cultured
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Colony Count, Microbial
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Cytokines / analysis
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Cytokines / metabolism
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Endometriosis / chemically induced
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Endometriosis / etiology*
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Endometriosis / microbiology
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Endometriosis / pathology
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Endotoxins / blood
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Endotoxins / toxicity*
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Escherichia coli Infections / blood
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Escherichia coli Infections / complications*
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Escherichia coli Infections / pathology
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Female
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Humans
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Menstruation / blood*
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Peritoneal Diseases / chemically induced
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Peritoneal Diseases / etiology*
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Peritoneal Diseases / microbiology
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Peritoneal Diseases / pathology
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Young Adult
Substances
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Cytokines
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Endotoxins
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endotoxin, Escherichia coli