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    CG31140 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42836, updated on 26-Apr-2024

    Summary

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    Official Symbol
    CG31140provided by FlyBase
    Primary source
    FLYBASE:FBgn0051140
    Locus tag
    Dmel_CG31140
    See related
    AllianceGenome:FB:FBgn0051140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13600; CG31452; CG5875; DGKt; Dmel\CG31140
    Summary
    Predicted to enable diacylglycerol kinase activity. Predicted to be involved in G protein-coupled receptor signaling pathway and protein kinase C signaling. Predicted to be located in cytoplasm and nucleus. Is expressed in adult head. Orthologous to human DGKQ (diacylglycerol kinase theta). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    95D1-95D4; 3-82 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23963180..23983232)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19788902..19808954)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glutamyl-prolyl-tRNA synthetase Neighboring gene antisense RNA:CR46092 Neighboring gene Adaptor Protein complex 1, sigma subunit Neighboring gene mimi Neighboring gene mir-9381 stem loop Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evaluation of the genomic extent of effects of fixed inversion differences on intraspecific variation and interspecific gene flow in Drosophila pseudoobscura and D. persimilis. Machado CA, et al. Genetics, 2007 Mar. PMID 17179068, Free PMC Article
    2. Identification and in silico modeling of enhancers reveals new features of the cardiac differentiation network. Seyres D, et al. Development, 2016 Dec 1. PMID 27899510
    3. Topological organisation of the phosphatidylinositol 4,5-bisphosphate-phospholipase C resynthesis cycle: PITPs bridge the ER-PM gap. Cockcroft S, et al. Biochem J, 2016 Dec 1. PMID 27888240
    4. Sensory-neuron subtype-specific transcriptional programs controlling dendrite morphogenesis: genome-wide analysis of Abrupt and Knot/Collier. Hattori Y, et al. Dev Cell, 2013 Dec 9. PMID 24290980
    5. Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. Renault AD, et al. Mech Dev, 2002 Dec. PMID 14516700

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein kinase C signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31140-PA
    CG31140-PB
    CG31140-PD
    CG31140-PE
    CG31140-PF
    CG31140-PG
    CG31140-PH
    NP_001097894.1
    NP_001097895.1
    NP_001247275.1
    NP_001262893.1
    NP_651199.2
    NP_996275.2
    NP_996276.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23963180..23983232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206553.4 → NP_996276.1  uncharacterized protein Dmel_CG31140, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996276.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KS35
      Conserved Domains (8) summary
      smart00109
      Location:69 → 116
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00046
      Location:612 → 757
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:6 → 55
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00130
      Location:135 → 185
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00609
      Location:825 → 980
      DAGK_acc; Diacylglycerol kinase accessory domain
      pfam00788
      Location:324 → 413
      RA; Ras association (RalGDS/AF-6) domain
      cl00155
      Location:414 → 513
      UBQ; Ubiquitin-like proteins
      cl17169
      Location:523 → 593
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_142942.6 → NP_651199.2  uncharacterized protein Dmel_CG31140, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651199.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCF2
      Related
      FBpp0083885
      Conserved Domains (8) summary
      smart00109
      Location:69 → 116
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00046
      Location:1121 → 1266
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:6 → 55
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00130
      Location:135 → 185
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00609
      Location:1334 → 1489
      DAGK_acc; Diacylglycerol kinase accessory domain
      pfam00788
      Location:833 → 922
      RA; Ras association (RalGDS/AF-6) domain
      cl00155
      Location:923 → 1022
      UBQ; Ubiquitin-like proteins
      cl17169
      Location:1032 → 1102
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001260346.1 → NP_001247275.1  uncharacterized protein Dmel_CG31140, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247275.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K716
      Conserved Domains (8) summary
      smart00109
      Location:69 → 116
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00046
      Location:1055 → 1200
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:6 → 55
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00130
      Location:135 → 185
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00609
      Location:1268 → 1423
      DAGK_acc; Diacylglycerol kinase accessory domain
      pfam00788
      Location:767 → 856
      RA; Ras association (RalGDS/AF-6) domain
      cl00155
      Location:857 → 956
      UBQ; Ubiquitin-like proteins
      cl17169
      Location:966 → 1036
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_206552.4 → NP_996275.2  uncharacterized protein Dmel_CG31140, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996275.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJR9, Q7KS34
      Conserved Domains (9) summary
      smart00109
      Location:69 → 116
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00046
      Location:612 → 737
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:612 → 945
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00029
      Location:6 → 55
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00130
      Location:135 → 185
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00609
      Location:773 → 928
      DAGK_acc; Diacylglycerol kinase accessory domain
      pfam00788
      Location:324 → 413
      RA; Ras association (RalGDS/AF-6) domain
      cl00155
      Location:414 → 513
      UBQ; Ubiquitin-like proteins
      cl17169
      Location:523 → 593
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_001104424.3 → NP_001097894.1  uncharacterized protein Dmel_CG31140, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097894.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR94
      Conserved Domains (8) summary
      smart00109
      Location:69 → 116
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00046
      Location:1121 → 1266
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:6 → 55
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00130
      Location:135 → 185
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00609
      Location:1302 → 1457
      DAGK_acc; Diacylglycerol kinase accessory domain
      pfam00788
      Location:833 → 922
      RA; Ras association (RalGDS/AF-6) domain
      cl00155
      Location:923 → 1022
      UBQ; Ubiquitin-like proteins
      cl17169
      Location:1032 → 1102
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. NM_001275964.1 → NP_001262893.1  uncharacterized protein Dmel_CG31140, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262893.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHZ4
      Conserved Domains (8) summary
      smart00109
      Location:69 → 116
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00046
      Location:1121 → 1266
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:6 → 55
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00130
      Location:135 → 185
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00609
      Location:1302 → 1457
      DAGK_acc; Diacylglycerol kinase accessory domain
      pfam00788
      Location:833 → 922
      RA; Ras association (RalGDS/AF-6) domain
      cl00155
      Location:923 → 1022
      UBQ; Ubiquitin-like proteins
      cl17169
      Location:1032 → 1102
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. NM_001104425.2 → NP_001097895.1  uncharacterized protein Dmel_CG31140, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097895.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PB4
      Conserved Domains (3) summary
      cd00029
      Location:6 → 55
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00130
      Location:135 → 185
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl00040
      Location:69 → 116
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K716 A0A0B4K716
    A0A0B4KHZ4 A0A0B4KHZ4
    A8JR94 A8JR94
    Q7KS34 Q7KS34
    Q7KS35 Q7KS35
    Q86PB4 Q86PB4
    Q95T86 Q95T86
    Q9VCF2 Q9VCF2

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