MICU1 Mitochondrial calcium uptake 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: MICU1provided by FlyBase
Official Full Name: Mitochondrial calcium uptake 1provided by FlyBase
Primary source: FLYBASE:FBgn0031893
Locus tag: Dmel_CG4495
See related: AllianceGenome:FB:FBgn0031893
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4495; Dmel\CG4495; micu1
Summary: Predicted to enable calcium ion binding activity. Involved in anesthesia-resistant memory; calcium import into the mitochondrion; and medium-term memory. Predicted to be part of uniplex complex. Is expressed in several structures, including adult head; anterior endoderm anlage; embryonic/larval midgut; germ layer; and posterior midgut primordium. Used to study myopathy with extrapyramidal signs. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (7182234..7185529)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (7182234..7185529)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

MICU1 mutants are developmentally lethal, consistent with unregulated Ca2+ uptake.
Title: Comprehensive Genetic Characterization of Mitochondrial Ca(2+) Uniporter Components Reveals Their Different Physiological Requirements In Vivo.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in anesthesia-resistant memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium import into the mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium import into the mitochondrion	TAS Traceable Author Statement more info	PubMed
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of uniplex complex	IBA Inferred from Biological aspect of Ancestor more info
part_of uniplex complex	ISS Inferred from Sequence or Structural Similarity more info
part_of uniplex complex	TAS Traceable Author Statement more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain