BIBLIOGRAPHY
ARTICLES
1. Di Giamberardino L. & de Haën C.: Sulla cinetica di dissociazione e sulla struttura dell'emocianina di Eriphia spinifrons. Rapporti dei Laboratori di Fisica dell'Istituto Superiore di Sanità 65/5:1-44,1965.
2 Toschi G., Dore E., Angeletti P.U., Levi-Montalcini R. & de Haën C.: Characteristics of labelled RNA from spinal ganglia of chick embryo and the action of a specific growth factor (NGF). J. Neurochem. 13: 539-544,1966.
3. de Haën C.: Versuche zu einer chemischen Fraktionierungsmethode für Transfer-ribonucleinsäuren. Diss. Nr. 4388, Eidgenoessische Technische Hochschule Zürich, 1970.
4. de Haën C.: Adenylate cyclase. A new kinetic analysis of the effects of hormones and fluoride ion. J. Biol. Chem. 249:2756-2762, 1974.
5. de Haën C. & Gertler A.: Isolation and amino-terminal sequence analysis of two dissimilar pancreatic proelastases from the African lungfish, Protopterus aethiopicus. Biochemistry 13:2673-2677,1974.
6. de Haën C., Neurath H. & Teller D.C.: The phylogeny of trypsin related serine proteases and their zymogens. New methods for the investigation of distant evolutionary relationships. J. Mol. Biol. 92:225-259, 1975.
7. de Haën C. & Neurath H.: Protein structure and the evolution of species, in "Biochemical and Biophysical Perspectives in Marine Biology", Vol 3 (Malins D.C. & Sargent, J.R., eds), pp. 1-65, Academic Press, London, 1976.
8. de Haën C.: The non-stoichiometric floating receptor model for hormone-sensitive adenylyl cyclase. J. Theoret. Biol. 58:383-400, 1976.
9. Teller D.C., Titani K. & de Haën C.: Amino acid sequence data on trypsin-related serine proteases. In "Handbook of Biochemistry and Molecular Biology", Vol 3 (Fasman G., ed.), 3rd edition, , pp. 340-366, CRC Press, Cleveland, Ohio, 1976.
10. de Haën C., Swanson E. & Teller D.C.: An easy method for retrieving atomic coordinates from CPK space filling molecular models. Biopolymers 15:1825-1833, 1976.
11. de Haën C., Swanson E. & Teller D.C.: The evolutionary origin of proinsulin. Amino acid sequence homology with trypsin-related serine proteases detected and evaluated by new statistical methods. J. Mol. Biol. 106:639-661,1976.
12. de Haën C., Walsh K.A. & Neurath H.: Isolation and amino-terminal sequence analysis of a new pancreatic trypsinogen of the African lungfisch Protopterus aethiopicus. Biochemistry 16:4421-4425, 1977.
13. Swanson E., Teller D.C. & de Haën C.: The low Reynolds number translational friction of ellipsoids, cylinders, dumbbells and hollow spherical caps. Numerical testing of the validity of the modified Oseen tensor in computing the friction of objects modeled as beads on a shell. J. Chem. Phys. 68:5097-5102, 1978.
14. May J.M., Williams R.H. & de Haën C.: NεB29-(+)-Biotinylinsulin and its complexes with avidin. Synthesis and biological activity. J. Biol. Chem. 253:686-690, 1978.
15. de Haën C., Little S.A., May J.M. & Williams R.H.: Characterization of proinsulin-insulin intermediates in human plasma. J. Clin. Invest. 62:727-737,1978.
16. de Haën C. & Teller D.C.: How do proteins change function in the course of evolution?. In "Evolution of Protein Molecules", (Matsubara H. & Yamanaka T., eds.) pp. 149-160, Japan Scientific Societies Press, Tokyo, 1978.
17. Teller D.C., Swanson, E. & de Haën C.: The translational friction coefficient of proteins. Methods in Enzymology 61:103-124, 1979.
18. Johnson D.G. & de Haën C.: 2,4-Diamino-5-cyano-6-halopyridines and analogues. A new family of insulin secretogogues that resemble glucose in hydrogen bonding possibilities. Mol. Pharmacol. 15:287-293, 1979.
19. May J.M. & de Haën C.: Insulin-stimulated intracellular hydrogen peroxide production in rat epididymal fat cells. J. Biol. Chem. 254:2214-2220, 1979.
20. Ross J.B.A., Rousslang K.W., de Haën C., Lavis V.R. & Deranleau D.A.: 12-Homoarginine glucagon: synthesis and observations on conformation, biological activity and copper-mediated peptide cleavage. Biochim. Biophys. Acta 576:372-384, 1979.
21. May J.M. & de Haën C.: The insulin-like effect of hydrogen peroxide on pathways of lipid synthesis in rat adipocytes. J. Biol. Chem. 254:9017-9021, 1979.
22. Swanson E., Teller D.C. & de Haën C.: Creeping flow translational resistance of rigid assemblies of spheres. J. Chem. Phys. 72:1623-1628, 1980.
23. de Haën C., Muchmore D.B. & Little S.A.: Stimulation of intracellular H2O2 production in rat adipocytes by insulin, insulin-fragments, and other hormones and growth factors with insulin-like activities. In "Insulin, chemistry structure and function of insulin and related hormones" (Brandenburg D. & Wollmer A., eds.), Proc. 2nd. Int. Insulin Symposium, Aachen, West Germany, pp. 461-468, Walter de Gruyter Inc., Berlin, 1980.
24. Little S.A. & de Haën C.: Effects of hydrogen peroxide on basal and hormone-stimulated lipolysis in perifused rat fat cells in relation to the mechanism of action of insulin. J. Biol. Chem. 255:10888-10895, 1980.
25. Muchmore D.B., Little S.A. & de Haën C.: A dual mechanism of action of ocytocin in rat epididymal fat cells. J. Biol. Chem. 256:365-372,1981 (Oxytocin).
26. Muchmore D.B., Little S.A. & de Haën C.: Counter-regulatory control of intracellular hydrogen peroxide production by insulin and lipolytic hormones in isolated rat epididymal fat cells: A role of free fatty acids. Biochemistry 21:3886-3892, 1982.
27. Porte D. Jr., Halter J.B., de Haën C., Palmer J.P., Asplin, C.M., Graf R.J. & Pfeifer, M.A.: "Diabetes mellitus". In "Contemporary Metabolism", Vol 2, Chapt. 1 (Freinkel N., ed.), pp.1-59, Plenum Press, New York, 1982.
28. Muchmore D.B., Raess B.U., Bergstrom R.W. & de Haën C.: On the mechanism of inhibition of insulin action by small molecular weight trypsin inhibitors. Diabetes 31:976-984, 1982.
29. Lipkin, E.W. & de Haën C.: The lack of insulin mimetic and antagonistic effects of methyl-α- D-mannoside in iso-osmolar solutions. Biochim.
Biophys. Acta 721:119-123, 1982.
30. Lipkin E.W., Teller D.C. & de Haën C.: Dynamic aspects of insulin action: Synchronization of oscillatory glycolysis in isolated perifused rat fat cells by insulin and hydrogen peroxide. Biochemistry 22:792-799, 1983.
31. de Haën C., Easterly R.A. & Teller D.C.: Translational friction of rigid assemblies of spheres: Derivation and application of new hydrodynamic interaction tensors. Biopolymers 22:1133-1143, 1983.
32. Raess B.U., Muchmore D.B. & de Haën C.: Glycogen synthesis stimulation by adenylate cyclase inhibition in rat epididymal adipocytes. Biochemistry 22:2214-2221, 1983.
33. Lipkin E.W., Teller D.C. & de Haën C.: Insulin binding to rat epididymal fat cells. Proc. 2nd International Symp. on Insulin Receptors and Insulin Action, Rome, 8/31-9/3, 1983, p. 21.
34. de Haën C., Nist B.J., Hansen R.S., Johnson, D.G.& Thompson W.J.: 2,4-Diamino-5-cyano-6-halopyridines: A new class of cyclic AMP phosphodiesterase inhibitors with therapeutic potential. Biochem. Pharmacol. 33:2109-2113, 1984.
35. Smith P.F., Thompson W.J., de Haën C., Halonen, M. Palmer, J.D. & Johnson, D.G.: Bronchodilator activity of a non-xanthine phosphodiesterase inhibitor; 2,4-Diamino-5-cyano-6-bromopyridine (Compound I). J. Pharmacol. Exp. Ther. 237:114-119, 1986.
36. Lipkin E.W., Teller D.C. & de Haën C: Equilibrium binding of insulin to rat white fat cells at 15°C. J. Biol. Chem. 261:1694-1701, 1986.
37. Lipkin E.W., Teller D.C. & de Haën C.: Kinetics of insulin binding to rat white fat cells at 15°C. J. Biol. Chem. 261:1702-1711, 1986.
38. de Haën C.: Molecular weight standards for calibration of gel filtration and SDS-polyacrylamide gel electrophoresis: Ferritin and apoferritin. Anal. Biochem. 166:23-245, 1987.
39. Reeck G.R., de Haën C., Teller D.C., Doolittle R.F., Fitch W.M., Dickerson R.E., Chambon P., McLachlan A.D., Margoliash E., Jukes. T.H. & Zuckerkandl E.: "Homology" in proteins and nucleic acids: A terminology muddle and a way out of it. Cell 50:667, 1987.
40. Phillips P.E., Lipkin E.W. & de Haën C.: Enhancement of insulin binding to rat white adipocytes at 15°C by 5,5'-dithiobis-(2-nitrobenzoic acid). Independence of the reagent's sulfhydryl group reactivity. J. Biol. Chem. 263:11175-11182, 1988.
41. Ahn N.G., Teller D.C., Bienkowski M.J., McMullen B.A., Lipkin E.W., & de Haën C.: Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor. J. Biol. Chem. 263:18657-18663, 1988.
42. Broudy V.C., Lin N., Egrie J., de Haën C., Weiss T., Papayannopoulou, T. & Adamson, J.W.: Identification of the receptor for erythropoetin on human and murine erythroleukemia cells and modulation by phorbol ester and dimethylsulfoxide. Proc. Nat. Acad. Sci. USA. 85:6513-6517, 1988.
43. Bergstrom R.W., Fujimoto W.Y., Teller D.C. & de Haën C.: Oscillatory insulin secretion in perifused isolated rat islets. Am. J. Physiol. 257: E479-E485, 1989.
44. Cavagna F., Tirone P., Felder E. & de Haën C.: Hepatobiliary contrast agents for magnetic resonance imaging, in "Liver Imaging. Current Trends and New Techniques" (Ferrucci J.T. and Stark D.D., eds.) pp. 384-393, Andover Medical Publishers Inc., Boston MA (1990).
45. Cavagna F., Tirone P., Felder E. & de Haën C.: Gd‑BOPTA/ Dimeg, a new hepatobiliary contrast agent for magnetic resonance imaging. Proceeding 2nd Special Topic Seminar: New developments in contrast agent research Bordeaux, France Sept. 26-28 (1990). In "New Developments in Contrast Agent Research" (P.A. Rinck and R.N. Muller, eds.) pp. 83-94, European Magnetic Resonance Forum, Blonay, Switzerland, 1991.
46. Reniero R., Morelli L., de Haën C. & Bottazzi V.: Detection of permanent Lactobacillus casei, subsp. casei strains in weaned infants' gut. Lett. Appl. Microbiol. 13:3-6, 1991.
47. Cavagna F., Daprà M., Maggioni F., de Haën C. & Felder E.: Gd-BOPTA/Dimeg: Experimental Disease Imaging. Magnetic Reson. Med. 22:329-333, 1991.
48. Rosati G. & de Haën C.: Considerations about the research and development of new X‑ray contrast media. A critical appraisal. 2nd Intern. Symp. Contrast Media, Osaka, Japan, November 8-10, 1990. In "New Dimensions of Contrast Media" (Katayama H. and Brasch, R.C., eds.) pp. 29-34 Int. Congr. Series 976, Excerpta Medica, Amsterdam, 1991.
49. de Haën C. & La Ferla, R.: New aspects of osmotic pressure, flow, load, and bolus in adverse reactions and toxicity of contrast media. Invest. Radiol. 26, Suppl. 1:S26-S28, 1991.
50. Davies A. & de Haën C.: Gadobenic acid dimeglumine salt. Contrast agent for magnetic resonance imaging. Drugs Fut. 16:1001-1003, 1991.
51. Maisano F., Gozzini, L. & de Haën C.: Coupling of DTPA to proteins: A critical analysis of the cyclic dianhydride method in the case of insulin modification. Bioconjugate Chem. 3:212-217, 1992.
52. de Haën C. & Gozzini L.: Soluble type hepatobiliary contrast agents for MR Imaging. J. Magn. Reson. Imag. 3:179-186, 1993.
53. Gallotti A., Uggeri F., Favilla A., Cabrini M. & de Haën C.: The chemistry of iomeprol and physico-chemical properties of its aqueous solutions and pharmaceutical formulations. Eur. J. Radiol. 18 (Suppl. 1):S1-S12, 1994.
54. Lorusso V., Luzzani F., Bertani F., Tirone P. & de Haën C.: Pharmacokinetics and tissue distribution of iomeprol in animals. Eur. J. Radiol 18 (Suppl. 1):S13-S20, 1994.
55. Morisetti A., Tirone P., Luzzani F. & de Haën C.: Toxicological safety assessment of iomeprol, a new X-ray contrast agent. Eur. J. Radiol.  18 (Suppl. 1):S21-S31, 1994.
56. Cipolla P., Tirone P., Luzzani F. & de Haën C.: Pharmacodynamic effects of iomeprol for injection in experimental animal studies. Eur. J. Radiol. 18 (Suppl. 1):S32-S42, 1994.
57. La Noce A., Bertani F., Lorusso V., Luzzani F., Tirone P. & de Haën C.: Preclinical safety assessment of iomeprol for injection as contrast medium for myelography. Eur. J. Radiol. 18 (Suppl. 1):S43-S50, 1994.
58. de Haën C., Morisetti A., Bertani F. & Tirone P.: The factor time in acute intravenous toxicity studies of contrast media. Invest. Radiol.29 (Suppl. 2):S108-S110, 1994.
59. Cavagna F.M., Marzola P., Daprà M., Maggioni F., Vicinanza E., Castelli P.M., de Haën C., Luchinat C., Wendland M.F., Saeed M. & Higgins C.B.: Binding of gadobenate dimeglumine to proteins extravasated into interstitial space enhances conspicuity of reperfused infarcts. Invest. Radiol. 29 (Suppl. 2):S50-S53, 1994.
60. Uggeri F., Aime S., Anelli P.L., Botta M., Brocchetta M., de Haën C., Ermondi G., Grandi M. & Paoli P.: Novel contrast agents for magnetic resonance imaging. Synthesis and characterization of the ligand BOPTA and its Ln(III) complexes (Ln = Gd, La, Lu). X-ray structure of disodium (TPS-9-145337286-C-S)-[4-carboxy-5,8,11-tris (carboxymethyl)-1-phenyl-2-oxa-5,8,11-triazatridecan-13-oato(5-)]gadolinate(2-) in a mixture with its enantiomer. Inorg. Chem. 34(3):633-642, 1995.
61. de Haën C., Lorusso V., Luzzani F. & Tirone P.: Hepatic transport of the Magnetic Resonance Imaging agent gadobenate dimeglumine in the rat. Acad. Radiol. 2(3), 232-238, 1995.
62. Cipolla P., Castano M., Kirchin M., de Haën C. & Tirone P.: Effects of iodinated contrast media on pulmonary airway resistance in anaesthetized guinea pigs. Acad. Radiol. (Stockholm) 2(4), 306-312, 1995.
63. de Haën C.: CT and new contrast media widen diagnostic options. Diagnostic Imaging Europe, Supplement, pp. CM32-33 and CM40, June 1995; also: I nuovi mezzi di contrasto e le tecniche di TC ampliano le possibilità diagnostiche. Diagnostic Imaging Europe, Supplement, pp. MC32-MC33, June 1995.
64. Anelli P.L., de Haën C., Fedeli F., Murru M. & Uggeri F.: A new approach to hepatospecific MRI contrast agents for magnetic resonance imaging (MRI). Gadolinium complexes conjugated to hepatotropic polyiodinated synthons. In “Macrocyclic and supramolecular chemistry in Italy” (Savelli G., ed.). Proc. 2nd Natl. Congress on Supramolecular Chemistry, Perugia, Sept. 1994, pp. 307-311, Centro Stampa Università degli Studi di Perugia, May 1995.
65. Luzzani F.L. & de Haën C.: Iofratol. Drugs Fut. 20(11), 1120-1122, 1995.
66. Anelli P.L., de Haën C., Fedeli F., Murru M. & Uggeri F.: New targeted MRI contrast agents. In “New Developments in Contrast Agent Research” (P.A. Rinck and R.N. Muller, eds.). Proceedings 4th Special Topic Seminar: New Developments in Contrast Agent Research, Santiago de Compostela, Spain, Sept. 28-30, 1994, pp. 29-36, European Magnetic Resonance Forum Foundation, Mons, Belgium, 1995.
67. La Noce A., Danieli A., Bertani F., Tirone P. & de Haën C.: Conditioned taste aversion in rats following intrathecal administration of contrast media. Acta Radiol. (Stockholm) 37, 116-120, 1996.
68. Anelli P.L., Calabi L., de Haën C., Fedeli F., Losi P., Murru M. & Uggeri F.: A new approach to hepatospecific MRI contrast agents: Gadolinium complexes conjugated to iodinated synthons. Gazz. Chim. Ital. 126, 89-97, 1996.
69. de Haën C., Lorusso V. & Tirone P.: Hepatic transport of gadobenate dimeglumine in TR- rats. Acad. Radiol. 3 (Suppl. 2), S452-S454, 1996.
70. Luzzani F., Morisetti A., Bussi S., Tirone P. & de Haën C.: Neurotolerability of non-ionic X-ray contrast media: the role of chemotoxicity. Invest. Radiol. 31(6), 338-344, 1996.
71. Anelli P.L., Calabi L., de Haën C., Lattuada L., Lorusso V., Maiocchi A., Morosini P., & Uggeri F.: Hepatocyte-directed MR contrast agents – Can we take advantage of bile acids? Acta Radiol./Supplementum, 412, 125-134, 1997.
72. Luzzani F., Cipolla P., Pélaprat M.L., Robert F., Gotti C., Tirone P. & de Haën C.: Brain penetration and neurological effects of gadobenate dimeglumine in the rat. Acta Radiol. (Stockholm) 38(2), 268-272, 1997.
73. Drago L., Gismondo M. R., Lombardi A., de Haën C., & Gozzini L.: Inhibition of in vitro growth of enteropathogens by new Lactobacillus isolates of human intestinal origin. FEMS Microbiol. Lett. 153(2), 455-463, 1997.
74. Morelli L., Cesena C., de Haën C., & Gozzini L.: Taxonomic Lactobacillus composition of faeces from human new-borns during the first few days. Microbial Ecol. 35, 205-212, 1998.
75. de Haën C.: La Bracco nella ricerca dei contrasti radiologici. Cronache Farmaceutiche 41(3), 138-141, 1998.
76. Moncelli M.R., Becucci L., de Haën C. & Tirone P.: Interactions between magnetic resonance imaging contrast agents and phospholipid monolayers. Bioelectrochem. Bioenerg. 46, 205-213, 1998
77. Morcos S.K., Dawson P., Pearson J.D., Jeremy J.Y., Davenport A.P., Yates M.S., Tirone P., Cipolla P., de Haën C., Muschick P., Krause W., Refsum H., Emery, C.J., Liss P., Nygren A., Haylor J., Pugh N.D. & Karlsson J.O.G.: The haemodynamic effects of iodinated water soluble radiographic contrast media: a review. Eur. J. Radiol. 29(1) 31-46, Nov., 1998.
78. de Haën C., Cabrini M., Akhnana L., Ratti D., Calabi L. & Gozzini L.: Gadobenate dimeglumine 0.5 M solution for injection (MultiHance®): Pharmaceutical formulation and physico-chemical properties of a new magnetic resonance imaging contrast medium. J. Comput. Assist. Tomogr. 23 (Suppl. 1), S161-S168, 1999.
79. de Haën C., La Ferla R. & Maggioni F.: Gadobenate dimeglumine 0.5 M solution for injection (MultiHance®) as a contrast agent for magnetic resonance imaging of the liver. Mechanistic studies in animals. J. Comput. Assist. Tomogr. 23 (Suppl. 1), S169-S179, 1999.
80. Lorusso V., Arbughi T., Tirone P. & de Haën C.: Pharmacokinetics and tissue distribution in animals of gadobenate ion, the contrast enhancing component of gadobenate dimeglumine 0.5 M solution for injection (MultiHance®). J. Comput. Assist. Tomogr. 23 (Suppl. 1), S181-S194, 1999.
81. Tirone P., Castano M., Cipolla P., Frigeni V., La Noce A., Luzzani F., Valenti R. & de Haën C.: General Pharmacology in experimental animals of gadobenate dimeglumine (MultiHance®), a new magnetic resonance imaging contrast agent. J. Comput. Assist. Tomogr. 23 (Suppl. 1), S195-S206, 1999.
82. Morisetti A., Bussi S., Tirone P. & de Haën C.: Toxicological safety evaluation of gadobenate dimeglumine 0.5 M solution for injection (MultiHance®), a new magnetic resonance imaging contrast medium. J. Comput. Assist. Tomogr. 23(Suppl. 1), S207-S217,1999.
83. de Haën C., Tsui-Auch L.-S. & Alexis M.: Multimodal organizational learning: From misbehavior to Good
Laboratory Practice in the pharmaceutical industry. In: Handbook of Organizational Learning and Knowledge (M.
Dierkes, A. Berthoin Antal, J. Child & I. Nonaka, eds.) pp. 902-918, Oxford University Press: New York, N.Y., 2001.
Edition in chinese: In: Organizational Learning and Knowledge Creation (M. Dierkes, A. Berthoin Antal, J. Child, I. Nonaka, Zhang X., eds.) pp. 698-711, Shanghai Peoples Publishing House: Shanghai, China, 2001.
Runner up with special mention for the George R. Terry Book Award of the American Academy of Management, 2002. Award criteria: Book published within the last two years; judged to have made the most outstanding contribution to the advancement of management knowledge; contribution can be to management theory, conceptualization, research or practice.
84. de Haën C.: Nuovi scenari della ricerca di mezzi di contrasto per imaging diagnostico. Boll. Chim. Farmac.(Milano, Italy) 140, 97-102, 2001.
85. de Haën C.: Die Benveniste-Affäre: Anlass zu Betrachtungen über das Phänomen,  die Dynamik und die Rolle von Aussenseitern und Aussteigern unter den Naturwissenschaftlern. In: Wo wären wir ohne die Verrückten? Zur Rolle von Außenseitern in Wissenschaft, Politik und Wirtschaft? (Meinolf Dierkes zum 60. Geburtstag, A. Berthoin Antal & C. Krebsbach- Gnath, eds.) pp. 83-98, Edition Sigma: Berlin, 2001.
86. de Haën C.: Conception of the first MRI contrast agents: A brief history. Topics Magn.Reson.Imag.12, 221-230, 2001.
87. de Haën C., Calabi L. & La Ferla R.: The problematic determination of proton magnetic relaxation rates of protein-containing solutions. Acad. Radiol. 9 (Suppl. 1), S2-S4, 2002.
88. Cavagna F.M., Lorusso V., Anelli P.L., Maggioni, F. & de Haën, C.: Preclinical profile and clinical potential of gadocoletic acid trisodium salt (B22956/1), a new intravascular contrast medium for MRI. Acad. Radiol. 9(Suppl. 2), S491-S494, 2002.
89. de Haën C.: Fallstudie zum eigenverantwortlichen Handeln: Die neue Pilotanlage. In: Eigenverantwortung für Organisationen (Koch, S., Kaschube, J. & Fisch, R., eds.) pp. 13-16, Hogrefe-Verlag: Göttingen, 2003.
90.

de Haën C., Anelli P.L., Lorusso V., Morisetti A., Maggioni F., Zheng J., Uggeri F. &  Cavagna F.M.: Gadocoletic acid trisodium salt (22956/1): A new blood pool magnetic resonance contrast agent with application in coronary angiography. Invest. Radiol. 41, 279-291, 2006.
   

 

 

PATENTS
 
1. Cavagna F., Giovagnoni A., de Haën C. & Ercolani P. (Bracco SpA, Milano): Method and formulations useful to improve the studies of human body cavities. WO9310821, June 10, 1993,  Priority date Nov. 29, 1991.
2. Cavagna F., de Haën C. Daprà M., Maggioni F. & Vicinanza E.  (Bracco SpA, Milano): Mezzi di contrasto per imaging cardiaco. IT 1245352, Sept. 20, 1994., Priority date March 19, 1991.
3. Cavagna F., de Haën C. Daprà M., Maggioni F. & Vicinanza E.  (Bracco SpA, Milano): Mezzi di contrasto per imaging del miocardio e della milza. IT 1249314, Feb. 22, 1995, Priority date May 23, 1991.
4. Felder E. & de Haën C. (Bracco SpA, Milano): Aqueous injectable formulations useful for radiodiagnosis comprising iodinated aromatic compounds used as X-ray contrast media. US 5,695,742, Priority date, Dec. 24, 1992.
5. Uggeri F., Anelli P.-L., Fedeli F., Murru M. & de Haën C. (Dibra SpA, Milano): Iodinated paramagnetic chelates and their use as contrast agents. US 5,660,814, Aug. 26, 1997, Priority Date June 2 and 15, 1993.
6. Anelli P.-L., Brocchetta M., de Haën C., Gazzotti O., Uggeri F., Verona S. & Visigalli M. (Bracco SpA): Iodinated oligomeric compounds and diagnostic compositions containing the same. IT 1264690, Appl. WO95/01966, Priority date July 8, 1993.
7. de Haën C., Uggeri F., Gazzotti O., Brocchetta M. (Dibra SpA, Milano): Tetraiodopyrrole derivatives as contrast medium and as antiseptic. US 5,587,487, Dec. 24, 1996, Priority Date Dec. 23, 1993
8. de Haën C. & Canepa V. (Dibra SpA, Milano): Container for diagnostic contrast compositions. US 5,772,651, June 30, 1998. Priority Date Jan. 18, 1994.
9. Gozzini L., Muttoni, M. & de Haën C. (Bracco SpA & Dibra SpA, Milano): Branched polyoxaalkyl macromolecules, process for making them and their uses. US 5,780,644, July 14, 1998, Priority date March 18, 1994.
10. Gozzini L., Muttoni M. & de Haën C.: Binary-branched polyoxaalkylene macromolecules, processes for making them amd their uses. US 5,886,110, March 23, 1999, Priority Date March 18, 1994.
11. Anelli P.-L., de Haën C., Lattuada L., Morosini P. & Uggeri F.: Paramagnetic metal ion chelates and use thereof as contrast agents in magnetic resonance imaging. US 5,649,537, July 22, 1997, Priority Date May 26, 1994.
12. Morelli L., Bottazzi V., Gozzini L. & de Haën C. (Dibra SpA): Lactobacillus strains of human origin, their compositions and uses thereof. US Patent 5,709,857, Jan. 20, 1998. Priority Dates May 26 and Aug. 25, 1994.
13. de Haën C. (Dibra SpA, Milano): Process for the preparation of prefilled syringes without residual gas bubbles. US Patent 5,573,042, Nov. 12, 1996. Priority Date May 16, 1995.
14. de Haën C. & Gozzini L. (Bracco SpA, Milano): Pharmaceutical and diet formulations for the prophylaxis and treatment of gastrointestinal disorders. US Patent 6,007,808, Dec. 28, 1999. Priority Date June 23, 1995.
15. de Haën C., Gozzini L. & Muttoni M. (Dibra SpA, Milan): Use of dendrimeric-type macromolecules as catalysts or coadjuvants in phase transfer catalysis reactions. US Patent 5,705,667, Jan. 6, 1998, Priority Date, Aug. 2, 1995.
16. Gallotti A., de Haën C., Smith A.M., Eakins M.N. & Zodda J.P.(Bracco SpA): Device for the standardization of signal intensity in the magnetic resonance images formation technique. US Patent 6,031,376, Feb. 29, 2000. Priority Date Feb. 21, 1996.
17. Anelli P.-L., Brocchetta M., de Haën C., Gazzotti O., Lattuada L., Lux G., Manfredi G., Morosini P., Palano D., Serleti, M., Uggeri F. & Visigalli M. (Bracco Imaging SpA): Preparation of metal complexes of polyaminocarboxylate linked bile acid derivatives as blood pool agents for nuclear magnetic resonance diagnostics. US Patent 6,461,588, Oct. 8, 2002, Priority Date Dec. 23, 1998.
18. de Haën C., Beltrami A., Capelletti E., Lattuada L. & Virtuani L. (Bracco Imaging SpA): Bile acid conjugates with metal ion chelates and the use thereof. US Patent 6,803,030, Oct. 12, 2004, Priority Date Feb. 21, 2001.
19. de Haën C. & Maisano F. (Bracco Imaging SpA): Method for the selective and quantitative functionalization of immunoglobulin Fab fragments, conjugate compounds obtained with the same and compositions thereof. Patent Application WO2004/043492/A1, May 27, 2004, Priority Date Nov. 13, 2002.
20. de Haën C. (Bracco Imaging SpA): Agents for the diagnosis and treatment of tumours that expose altered proteins on the cell surface. Patent Application WO2004/043487/A1, May 27, 2004, Priority Date Nov. 14, 2002. 
21. de Haën C., Nunn A.D., Swenson R.E. (Bracco Imaging SpA): Improved linkers for radiopharmaceutical compounds. Patent Application WO2004/062574/A1, July, 29, 2004, Priority Date Dec. 23, 2003.
21. de Haën C. & Vittadini G. (Bracco Imaging SpA): Metodo per il trattamento e la prevenzione della nefropatia associate alla somministrazione di agenti di contrasto. Italian Patent Application. Priority Date June 4, 2004.
22. de Haën C. (Bracco Imaging SpA): Ultrasound imaging apparatus for ultrasound-guided surgery. European Patent Application. Priority Date: Oct. 13, 2004.
23. de Haën C. (Bracco Imaging SpA): Contrast agent formulation for the visualization of the lymphatic system. European Patent Application. Priority Date Oct. 8, 2004.
24. de Haën C., Nunn A.D. & Swenson R.: Improved linkers for pharmaceutical compounds. Patent Application US 60/439,722, Priority Date Jan. 13, 2003.

 

ABSTRACTS OF PRESENTATIONS AT CONGRESSES WITH CONTENTS NOT FULLY DISCLOSED IN FULL LENGTH PUBLICATION
 
1. Di Giamberardino, L. & de Haën C.: Dissociazione e struttura della emocianina di Eriphia. 2° Convegno Nazionale di Biofisica, Roma, 18-20 giugno, 1965. Rapporti dei Laboratori di Fisica dell'Istituto Superiore di Sanità 65(22):68-77, 1965.
2. Teller D.C. & de Haën C.: The frictional properties of proteins. Pacific Slope Biochemical Conference 17:2, 1975, University of California, Irvine.
3. de Haën C., Eggerman T.L., Ose M. & Williams R.H.: A hight yield preparation for radio-immunoassay of cyclic nucleotides from tissue estracts. Adv. Cyclic Nucleotide Res. 9:767, 1978.
4. May J.M., & de Haën C.: En face observation of rat fat cell insulin binding sites labeled with 1:1:1 complexes of NεB29-biotinylinsulin, avidin and ferritin. Diabetes 27, Suppl. 2, (abstr. 77), 1978.
5. Teller D.C. & de Haën C.: Hydrodynamic evaluation of a ribosome model: Comparison of experiments with calculated friction coefficients. Proceedings of the VIII International Biophysics Congress and the III Pan American Biochemistry Congress, 1981.
6. de Haën C., Gorray K.C. & Howland H.C.: A model for oscillatory and biphasic insulin secretion. Diabetes 30, Suppl. 1 (abstr. 456), 1981.
7. Muchmore D.B., Raess B.U. & de Haën C.: On the mechanism of insulin degradation by adipocytes as revealed by bacitracin inhibition. Clin. Res. 30:63A, 1982.
8. Muchmore D.B., Raess B.U. & de Haën C.: Loss of trichloracetic acid precipitability does not parallel loss of biological activity of insulin in fat cell interactions. Diabetes 31, Suppl. 1 (abstr. 494), 1982.
9. Johnson D.G., McGreary J.M., Thompson W.J. & de Haën C.: Inhibition of pancreatic islet phosphodiesterase by 2,4-diamino-5-cyano-6-bromopyridine. Adv. Cyclic Nucleotide Res. Protein Phosphorylation 16:419, 1984.
10. Ahn N.G., Lipkin E.W., Teller D.C. & de Haën C.: Coupling between insulin binding and activation of glucose transport in rat adipocytes. Fed. Proc. 45:1835 (abstr. 2068), 1986.
11. Bergstrom R.W., Fujimoto W.Y., Teller D.C. & de Haën C.: Oscillatory insulin secretion in perifused islets and superfused cultures of HIT cells. Clin. Res. 36:148A, 1988.
12. Bergstrom R.W., Fujimoto W.Y., Teller D.C. & de Haën C.: Oscillatory insulin release by a collection of perifused rat islets and cultures of superfused HIT cells. Endocrine Society 70th Annual Meeting, abstract p. 181, 1988.
13. Morisetti A., Bussi S., Bertani F., Grandi M., Tirone P. & de Haën C.: The contribution of osmotic load, volume and time required for administration to the toxicity of X-ray contrast media. VI Int. Congress Toxicol. Rome, June 28-July 3, 1992. Toxicol. Lett. Suppl.: p. 253, 1992.
14. Cavagna F., Maggioni F., Vicinanza E., de Haën C. & Stark, D.D.: Dynamic MR imaging of blood-born liver metastases in rats after bolus administration of Gd-BOPTA/Dimeg. 10th Annu. Meet. Soc. Mag. Res. Imaging, New York, April 25-29, 1992. J. Magn. Res. Imaging 2(P), S8 (abstr. 324), 1992.
15. de Haën C.: The earliest days of X-ray contrast agents. Book of abstracts p. 272, Röntgen Centenary Congress 1995, Birmingham UK, June 12-16, 1995.
16. Lorusso V., Morisetti A., Tirone P. & de Haën C.: Gadolinium release from paramagnetic contrast agents. 6th Special Topic Seminar, New Developments in Contrast Agent Research, Hof bei Salzburg, Austria, June 3-5, 1998.
17. de Haën C.: The classical ionic contrast media. Invited lecture in the session “History of contrast media” and parallel Electronic Presentation On-line # A-0078, European Congress of Radiology, Vienna, March 4-8, 2005.