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Alcoholic fatty liver disease

MedGen UID:
4666
•Concept ID:
C0015696
•
Disease or Syndrome
Synonyms: Alcoholic Fatty Liver; Fatty Liver, Alcoholic
SNOMED CT: Alcoholic fatty liver disease (50325005); Alcoholic fatty liver (50325005)
 
Monarch Initiative: MONDO:0021104

Definition

Lipid infiltration of the hepatic parenchymal cells that is due to alcohol abuse. The fatty changes in the alcoholic fatty liver may be reversible, depending on the amounts of triglycerides accumulated. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlcoholic fatty liver disease

Professional guidelines

PubMed

Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD).
Rong L, Zou J, Ran W, Qi X, Chen Y, Cui H, Guo J
Front Endocrinol (Lausanne) 2022;13:1087260. Epub 2023 Jan 16 doi: 10.3389/fendo.2022.1087260. PMID: 36726464Free PMC Article
Current treatment of non-alcoholic fatty liver disease.
Paternostro R, Trauner M
J Intern Med 2022 Aug;292(2):190-204. Epub 2022 Jul 7 doi: 10.1111/joim.13531. PMID: 35796150Free PMC Article
Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article

Recent clinical studies

Etiology

MAFLD: How is it different from NAFLD?
Gofton C, Upendran Y, Zheng MH, George J
Clin Mol Hepatol 2023 Feb;29(Suppl):S17-S31. Epub 2022 Nov 29 doi: 10.3350/cmh.2022.0367. PMID: 36443926Free PMC Article
MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease.
Eslam M, Sanyal AJ, George J; International Consensus Panel
Gastroenterology 2020 May;158(7):1999-2014.e1. Epub 2020 Feb 8 doi: 10.1053/j.gastro.2019.11.312. PMID: 32044314
Mechanisms of NAFLD development and therapeutic strategies.
Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ
Nat Med 2018 Jul;24(7):908-922. Epub 2018 Jul 2 doi: 10.1038/s41591-018-0104-9. PMID: 29967350Free PMC Article
Non-alcoholic fatty liver disease.
Maurice J, Manousou P
Clin Med (Lond) 2018 Jun;18(3):245-250. doi: 10.7861/clinmedicine.18-3-245. PMID: 29858436Free PMC Article
Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention.
Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J, Bugianesi E
Nat Rev Gastroenterol Hepatol 2018 Jan;15(1):11-20. Epub 2017 Sep 20 doi: 10.1038/nrgastro.2017.109. PMID: 28930295

Diagnosis

AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease.
Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, Abdelmalek MF, Caldwell S, Barb D, Kleiner DE, Loomba R
Hepatology 2023 May 1;77(5):1797-1835. Epub 2023 Mar 17 doi: 10.1097/HEP.0000000000000323. PMID: 36727674Free PMC Article
Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Non-alcoholic fatty liver disease.
Maurice J, Manousou P
Clin Med (Lond) 2018 Jun;18(3):245-250. doi: 10.7861/clinmedicine.18-3-245. PMID: 29858436Free PMC Article
Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention.
Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J, Bugianesi E
Nat Rev Gastroenterol Hepatol 2018 Jan;15(1):11-20. Epub 2017 Sep 20 doi: 10.1038/nrgastro.2017.109. PMID: 28930295
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases.
Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, Harrison SA, Brunt EM, Sanyal AJ
Hepatology 2018 Jan;67(1):328-357. Epub 2017 Sep 29 doi: 10.1002/hep.29367. PMID: 28714183

Therapy

GLP-1a: Going beyond Traditional Use.
Laurindo LF, Barbalho SM, Guiguer EL, da Silva Soares de Souza M, de Souza GA, Fidalgo TM, Araújo AC, de Souza Gonzaga HF, de Bortoli Teixeira D, de Oliveira Silva Ullmann T, Sloan KP, Sloan LA
Int J Mol Sci 2022 Jan 10;23(2) doi: 10.3390/ijms23020739. PMID: 35054924Free PMC Article
Therapeutic pipeline in nonalcoholic steatohepatitis.
Vuppalanchi R, Noureddin M, Alkhouri N, Sanyal AJ
Nat Rev Gastroenterol Hepatol 2021 Jun;18(6):373-392. Epub 2021 Feb 10 doi: 10.1038/s41575-020-00408-y. PMID: 33568794
Vitamin D and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): An Update.
Barchetta I, Cimini FA, Cavallo MG
Nutrients 2020 Oct 28;12(11) doi: 10.3390/nu12113302. PMID: 33126575Free PMC Article
Mechanisms of Cardiorenal Effects of Sodium-Glucose Cotransporter 2 Inhibitors: JACC State-of-the-Art Review.
Zelniker TA, Braunwald E
J Am Coll Cardiol 2020 Feb 4;75(4):422-434. doi: 10.1016/j.jacc.2019.11.031. PMID: 32000955
Mechanisms of NAFLD development and therapeutic strategies.
Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ
Nat Med 2018 Jul;24(7):908-922. Epub 2018 Jul 2 doi: 10.1038/s41591-018-0104-9. PMID: 29967350Free PMC Article

Prognosis

Burden of liver diseases in the world.
Asrani SK, Devarbhavi H, Eaton J, Kamath PS
J Hepatol 2019 Jan;70(1):151-171. Epub 2018 Sep 26 doi: 10.1016/j.jhep.2018.09.014. PMID: 30266282
Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis.
Younossi Z, Tacke F, Arrese M, Chander Sharma B, Mostafa I, Bugianesi E, Wai-Sun Wong V, Yilmaz Y, George J, Fan J, Vos MB
Hepatology 2019 Jun;69(6):2672-2682. doi: 10.1002/hep.30251. PMID: 30179269
Non-alcoholic fatty liver disease.
Maurice J, Manousou P
Clin Med (Lond) 2018 Jun;18(3):245-250. doi: 10.7861/clinmedicine.18-3-245. PMID: 29858436Free PMC Article
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases.
Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, Harrison SA, Brunt EM, Sanyal AJ
Hepatology 2018 Jan;67(1):328-357. Epub 2017 Sep 29 doi: 10.1002/hep.29367. PMID: 28714183
Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.
Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M
Hepatology 2016 Jul;64(1):73-84. Epub 2016 Feb 22 doi: 10.1002/hep.28431. PMID: 26707365

Clinical prediction guides

Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease.
Kanwal F, Shubrook JH, Adams LA, Pfotenhauer K, Wai-Sun Wong V, Wright E, Abdelmalek MF, Harrison SA, Loomba R, Mantzoros CS, Bugianesi E, Eckel RH, Kaplan LM, El-Serag HB, Cusi K
Gastroenterology 2021 Nov;161(5):1657-1669. Epub 2021 Sep 20 doi: 10.1053/j.gastro.2021.07.049. PMID: 34602251Free PMC Article
Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease.
Castera L, Friedrich-Rust M, Loomba R
Gastroenterology 2019 Apr;156(5):1264-1281.e4. Epub 2019 Jan 18 doi: 10.1053/j.gastro.2018.12.036. PMID: 30660725Free PMC Article
Liver fibrosis markers of nonalcoholic steatohepatitis.
Enomoto H, Bando Y, Nakamura H, Nishiguchi S, Koga M
World J Gastroenterol 2015 Jun 28;21(24):7427-35. doi: 10.3748/wjg.v21.i24.7427. PMID: 26139988Free PMC Article
Non-invasive diagnosis of advanced fibrosis and cirrhosis.
Sharma S, Khalili K, Nguyen GC
World J Gastroenterol 2014 Dec 7;20(45):16820-30. doi: 10.3748/wjg.v20.i45.16820. PMID: 25492996Free PMC Article
Histopathology of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article

Recent systematic reviews

Global prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in the overweight and obese population: a systematic review and meta-analysis.
Quek J, Chan KE, Wong ZY, Tan C, Tan B, Lim WH, Tan DJH, Tang ASP, Tay P, Xiao J, Yong JN, Zeng RW, Chew NWS, Nah B, Kulkarni A, Siddiqui MS, Dan YY, Wong VW, Sanyal AJ, Noureddin M, Muthiah M, Ng CH
Lancet Gastroenterol Hepatol 2023 Jan;8(1):20-30. Epub 2022 Nov 16 doi: 10.1016/S2468-1253(22)00317-X. PMID: 36400097
The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis.
Riazi K, Azhari H, Charette JH, Underwood FE, King JA, Afshar EE, Swain MG, Congly SE, Kaplan GG, Shaheen AA
Lancet Gastroenterol Hepatol 2022 Sep;7(9):851-861. Epub 2022 Jul 5 doi: 10.1016/S2468-1253(22)00165-0. PMID: 35798021
Nonalcoholic fatty liver disease as a metabolic disease in humans: A literature review.
Cariou B, Byrne CD, Loomba R, Sanyal AJ
Diabetes Obes Metab 2021 May;23(5):1069-1083. Epub 2021 Feb 10 doi: 10.1111/dom.14322. PMID: 33464677Free PMC Article
The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis.
Younossi ZM, Golabi P, de Avila L, Paik JM, Srishord M, Fukui N, Qiu Y, Burns L, Afendy A, Nader F
J Hepatol 2019 Oct;71(4):793-801. Epub 2019 Jul 4 doi: 10.1016/j.jhep.2019.06.021. PMID: 31279902
Nonalcoholic fatty liver disease: a systematic review.
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

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