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    NRG1 Nrg1p [ Candida albicans SC5314 ]

    Gene ID: 3643166, updated on 30-Nov-2023

    Summary

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    Gene symbol
    NRG1
    Gene description
    Nrg1p
    Locus tag
    CAALFM_C704230WA
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Candida albicans SC5314 (strain: SC5314, nat-host: Homo sapiens, culture-collection: ATCC:MYA-2876)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    1
    Sequence:
    Chromosome: 7; NC_032095.1 (918812..919744)

    Chromosome 7 - NC_032095.1Genomic Context describing neighboring genes Neighboring gene Ran GTPase-binding protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tpo2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_032095.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The transcriptional regulator Nrg1p controls Candida albicans biofilm formation and dispersion. Uppuluri P, et al. Eukaryot Cell, 2010 Oct. PMID 20709787, Free PMC Article
    2. Differential regulation of the transcriptional repressor NRG1 accounts for altered host-cell interactions in Candida albicans and Candida dubliniensis. Moran GP, et al. Mol Microbiol, 2007 Nov. PMID 17927699
    3. Hyphal induction under the condition without inoculation in Candida albicans is triggered by Brg1-mediated removal of NRG1 inhibition. Su C, et al. Mol Microbiol, 2018 May. PMID 29485686
    4. Transcript profiling reveals rewiring of iron assimilation gene expression in Candida albicans and C. dubliniensis. Moran GP. FEMS Yeast Res, 2012 Dec. PMID 22888912
    5. Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure. Muzzey D, et al. Genome Biol, 2013. PMID 24025428, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ngs1 binds to BRG1 promoter to induce its expression in GlcNAc.
      Title: Hyphal induction under the condition without inoculation in Candida albicans is triggered by Brg1-mediated removal of NRG1 inhibition.
    2. Candida albicans can express iron assimilation genes independently of NRG1 levels.
      Title: Transcript profiling reveals rewiring of iron assimilation gene expression in Candida albicans and C. dubliniensis.
    3. Nrg1p as a key regulator of the C. albicans biofilm life cycle.
      Title: The transcriptional regulator Nrg1p controls Candida albicans biofilm formation and dispersion.
    4. The increased rate of hypha formation in C. albicans relative to C. dubliniensis in response to phagocytosis by macrophages and serum was associated with rapid downregulation of NRG1 expression in C. albicans.
      Title: Differential regulation of the transcriptional repressor NRG1 accounts for altered host-cell interactions in Candida albicans and Candida dubliniensis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nrg1p
    XP_715199.1
    • Transcription factor/repressor; regulates chlamydospore formation/hyphal gene induction/virulence and rescue/stress response genes; effects both Tup1 dependent and independent regulation; flow model biofilm induced; Spider biofilm repressed

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_032095.1 Reference assembly

      Range
      918812..919744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_710106.1 → XP_715199.1  Nrg1p [Candida albicans SC5314]

      See identical proteins and their annotated locations for XP_715199.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A1D8PRJ2, Q3MNT7, Q5A0E5
      UniProtKB/TrEMBL
      C4YT53, G1UAC7, Q9C410
      Conserved Domains (3) summary
      sd00017
      Location:230 → 250
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:228 → 250
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:242 → 269
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version

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